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Dr. Williams is Professor of Medicine and Psychiatry. He is Director of the Durham VA Evidence Synthesis Program and Associate Director for the Duke Clinical Research Training Program. He teaches a masters level course on systematic review and meta-analysis. His research on the clinical examination, depression recognition, and methods to implement effective care models for depression have been published in major medical journals such as JAMA, BMJ and Annals of Internal Medicine. Dr. Williams has been actively involved in evidence synthesis with the AHRQ funded EPC’s in San Antonio and Duke. He has co-authored over 25 evidence syntheses including reviews on the medical home, antidepressants, and instruments to assess depression and anxiety disorders, and care management models for major depression. He is a member of the GRADE working group and the Mental Health QUERI, has co-chaired the VA/DOD Depression Guideline Panel and worked with other health care organizations on clinical guidelines and performance measures. Dr. Williams has mentored over 20 junior investigators, fostering the development of independent PIs for evidence synthesis projects.
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EDUCATION:
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- 1992 Duke University School of Medicine, Durham, NC, MHSc in Biometry
- 1984 University of North Carolina School of Medicine, Chapel Hill, NC, MD
- 1980 University of North Carolina, Chapel Hill, NC, BA - Chemistry
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POSTGRADUATE TRAINING:
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- 1988-1989 A.W. Mellon Fellow, Department of General Internal Medicine, Duke University Medical Center
- 1987-1988 Fellow, Department of General Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa
- 1984-1987 Resident, Department of General Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa
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PROFESSIONAL POSITIONS AND EXPERIENCE:
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- 2009-present Director, Durham VA Evidence Synthesis Center, Durham Veterans Affairs Medical Center, Durham, NC
- 2008-2009 Director, Evidence-based Practice Center, Duke University Medical Center, Durham, NC
- 2008-2009 Acting Director, Center for Clinical Health Policy Research, Duke University Medical Center, Durham, NC
- 2007 Associate Director, Clinical Research Training Program, Duke University Medical Center, Durham, NC
- 2004 Professor with Tenure, Department of General Internal Medicine, Duke University Medical Center, Durham, NC
- 2006 Professor with Tenure, Department of Psychiatry and Behavioral Sciences (secondary), Duke University Medical Center, Durham, NC
- 2001-2005 Associate Professor with Tenure, Department of Psychiatry and Behavioral Sciences (secondary), Duke University Medical Center, Durham, NC
- 2001-2004 Associate Professor with Tenure, Department of General Internal Medicine, Duke University Medical Center, Durham, NC
- 2001 Staff Physician and Research Scientist, Durham Veterans Affairs Medical Center, Durham, NC
- 1996-2001 Associate Professor with Tenure, Division of General Medicine, University of Texas Health Science Center, San Antonio, Texas
- 1992-01 Staff Physician, Audie L. Murphy Memorial Veterans Hospital, San Antonio, Texas
- 1992-1996 Assistant Professor, Division of General Medicine, University of Texas Health Science Center, San Antonio, Texas
- 1992-1996 Clinical Director, Continuity of Care Clinic, Audie L. Murphy Memorial Veterans Hospital, San Antonio, Texas
- 1992-1994 Co-Director, General Medicine Fellowship Program, Division of General Medicine, University of Texas Health Science Center, San Antonio
- 1991 Assistant Professor, Department of General Internal Medicine, Duke University Medical Center
- 1990-1991 Instructor, Department of General Internal Medicine, Duke University Medical Center
- 1990-1991 Research Associate, Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC
- 1990-1991 Medical Director, Hospital Based Home Care, Durham Veterans Affairs Medical Center, Durham, NC
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AWARDS AND HONORS:
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- 2008 Faculty of the Year Award, Duke Clinical Research Training Program
- 1998 Best Abstract Award, Society of General Internal Medicine-Southern Regional Meeting, New Orleans
- 1998 Elected to Southern Society for Clinical Investigation
- 1997-2000 Veterans Affairs Health Services Advanced Research Career Development Award
- 1993-1997 Robert Wood Johnson Generalist Physician Faculty Scholar
- 1988 A.W. Mellon Fellow, Duke University School of Medicine, Durham, NC
- 1983 Awarded Travel Fellowship, University of North Carolina School of Medicine for study of Obstetrics and Gynecology, University of Bristol, England
- 1981 Summer Fellowship to study Familial Antithrombin III Deficiency, University of North Carolina, Chapel Hill, NC
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TEACHING
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Classroom and Local Presentations
- April 2011 Inspired Teaching, Duke Center for Instructional Development Plenary Panel
- 2010 - present Clinical Research Training Program, Course 262 – Systematic Review and Meta-Analysis, Duke University School of Medicine, Course director (7, 1.5 hour sessions annually)
- April 2011 Shared Decision Making and Health Decision Aids
- March 2010 Antidepressant Drug Effects and Depression Severity: A Patient Level Meta-Analysis
- Nov 2009 Integrated Mental Health Services 2.0: Treating Warriors’ Hidden Wounds, Grand Rounds, Duke University Medical Center
- Sept 2007 The Unofficial Guide to the New Major Depression Guidelines, Grand Rounds – Geriatrics Division, Duke University Medical Center
- 2007 – 2008 Clinical Research Training Program, Course 249 (Health Services Research): Dissemination & Implementation Science, Duke University School of Medicine, Instructor (1.5 hour session annually)
Clinical Teaching
- 1988 – 2011 General Internal Medicine, Inpatient Ward
- 2011-present Internal Medicine Clinic
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RECENTLY FUNDED RESEARCH:
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Source: Agency for Healthcare Research and Quality (AHRQ) Title: Comprehensive EPC Comparative Effectiveness Reviews for Effective Healthcare Period: 10/26/2009 – 10/25/2012 Role: Co-Investigator for overall program PI: Patient Center Medical Home PI: Non-invasive Positive Pressure Ventilation: Comparative Effectiveness Review PI: Serious Mental Illness: Comparative Effectiveness of Interventions to Improve General Medical Outcomes
Source: VA Health Services Research and Development Account: ESP 0910 Title: Evidence Synthesis Program Period: 1/1/2010 – 12/31/2012 Role: PI for overall program
Source: VA Merit Review Account: VHA# 07-128 Title: Pregnenolone for Cognitive and Negative Symptoms in Schizophrenia Period: 4/1/2009 – 3/31/2012 Role: Co-Investigator
Source: Department of Defense Account: 151907/PTO75560 Title: PTSD-TBI Clinical Trials Consortium Period: 2008-2013 Role: Co-Investigator
Source: Veterans Affairs Health Services Research and Development Title: Center For Health Services Research in Primary Care Period: 10/1/09 – 9/30/12 Role: Co-Investigator
Source: Veterans Affairs Health Services Research and Development Title: Budget Impact to the VA of New Anticoagulants for Stroke Prevention in Atrial Fibrillation. Period: 12/12/11 – 9/30/12 Role: Co-Investigator
Source: Foundation for Informed Medical Decision Making Title: Evaluation of DVD and Internet Decision Aids for Hip and Knee Osteoarthritis: Focus on Health Literacy Period: 10/01/11 – 9/30/12 Role: Co-Investigator
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